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erdő Tűrhetetlen Azta overall mutation load and p53 mutations Repülési Lila Hihetetlen

Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome:  Cell
Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome: Cell

Mutant p53 elicits context-dependent pro-tumorigenic phenotypes | Oncogene
Mutant p53 elicits context-dependent pro-tumorigenic phenotypes | Oncogene

Low-burden TP53 mutations in CLL: clinical impact and clonal evolution  within the context of different treatment options - ScienceDirect
Low-burden TP53 mutations in CLL: clinical impact and clonal evolution within the context of different treatment options - ScienceDirect

Prognostic value of TP53 mutation location in breast cancer | CMAR
Prognostic value of TP53 mutation location in breast cancer | CMAR

Mutations of the p53 Gene as a Prognostic Factor in Aggressive B-Cell  Lymphoma | NEJM
Mutations of the p53 Gene as a Prognostic Factor in Aggressive B-Cell Lymphoma | NEJM

p53 Is the Most Frequently Mutated Gene in Cancer, but Can We Target It?
p53 Is the Most Frequently Mutated Gene in Cancer, but Can We Target It?

Gain of function in somatic TP53 mutations is associated with immune‐rich  breast tumors and changes in tumor‐associated macrophages - Behring - 2019  - Molecular Genetics & Genomic Medicine - Wiley Online Library
Gain of function in somatic TP53 mutations is associated with immune‐rich breast tumors and changes in tumor‐associated macrophages - Behring - 2019 - Molecular Genetics & Genomic Medicine - Wiley Online Library

Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune  escape through PHLPP2/AKT/PD-L1 pathway
Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathway

Frontiers | Promising New Tools for Targeting p53 Mutant Cancers: Humoral  and Cell-Based Immunotherapies
Frontiers | Promising New Tools for Targeting p53 Mutant Cancers: Humoral and Cell-Based Immunotherapies

Targeting a neoantigen derived from a common TP53 mutation | Science
Targeting a neoantigen derived from a common TP53 mutation | Science

Biomolecules | Free Full-Text | p53's Extended Reach: The Mutant p53  Secretome
Biomolecules | Free Full-Text | p53's Extended Reach: The Mutant p53 Secretome

A TP53-Associated Immune Prognostic Signature for the Prediction of Overall  Survival and Therapeutic Responses in Muscle-Invasive Bladder Cancer -  Frontiers
A TP53-Associated Immune Prognostic Signature for the Prediction of Overall Survival and Therapeutic Responses in Muscle-Invasive Bladder Cancer - Frontiers

Germline TP53 mutations undergo copy number gain years prior to tumor  diagnosis | Nature Communications
Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis | Nature Communications

TP53 mutations predict poor response to immunotherapy in patients with  metastatic solid tumors - Kim - 2023 - Cancer Medicine - Wiley Online  Library
TP53 mutations predict poor response to immunotherapy in patients with metastatic solid tumors - Kim - 2023 - Cancer Medicine - Wiley Online Library

Overall survival curves of patients with p53 mutation results. (A) p53... |  Download Scientific Diagram
Overall survival curves of patients with p53 mutation results. (A) p53... | Download Scientific Diagram

Cancers | Free Full-Text | TP53 Combined Phenotype Score Is Associated with  the Clinical Outcome of TP53-Mutated Myelodysplastic Syndromes
Cancers | Free Full-Text | TP53 Combined Phenotype Score Is Associated with the Clinical Outcome of TP53-Mutated Myelodysplastic Syndromes

Homogenous TP53mut-associated tumor biology across mutation and cancer  types revealed by transcriptome analysis | Cell Death Discovery
Homogenous TP53mut-associated tumor biology across mutation and cancer types revealed by transcriptome analysis | Cell Death Discovery

Omics analyses of a somatic Trp53R245W/+ breast cancer model identify  cooperating driver events activating PI3K/AKT/mTOR signaling | PNAS
Omics analyses of a somatic Trp53R245W/+ breast cancer model identify cooperating driver events activating PI3K/AKT/mTOR signaling | PNAS

Implications of driver genes associated with a high tumor mutation burden  identified using next‑generation sequencing on immunotherapy in  hepatocellular carcinoma
Implications of driver genes associated with a high tumor mutation burden identified using next‑generation sequencing on immunotherapy in hepatocellular carcinoma

Frequency of p53 mutations in human cancers. (A) Schematic picture... |  Download Scientific Diagram
Frequency of p53 mutations in human cancers. (A) Schematic picture... | Download Scientific Diagram

Acetylation halts missense mutant p53 aggregation and rescues tumor  suppression in non-small cell lung cancers - ScienceDirect
Acetylation halts missense mutant p53 aggregation and rescues tumor suppression in non-small cell lung cancers - ScienceDirect

The p53 network: cellular and systemic DNA damage responses in cancer and  aging: Trends in Genetics
The p53 network: cellular and systemic DNA damage responses in cancer and aging: Trends in Genetics

Survival of patients with p53 mutations in the DNA-binding motifs... |  Download Scientific Diagram
Survival of patients with p53 mutations in the DNA-binding motifs... | Download Scientific Diagram

LRP1B or TP53 mutations are associated with higher tumor mutational burden  and worse survival in hepatocellular carcinoma
LRP1B or TP53 mutations are associated with higher tumor mutational burden and worse survival in hepatocellular carcinoma

Evaluating the prognostic significance of p53 and TP53 mutations in  HPV-negative hypopharyngeal carcinoma patients: a 5-year follow-up  retrospective study | BMC Cancer | Full Text
Evaluating the prognostic significance of p53 and TP53 mutations in HPV-negative hypopharyngeal carcinoma patients: a 5-year follow-up retrospective study | BMC Cancer | Full Text

TP53 exon-6 truncating mutations produce separation of function isoforms  with pro-tumorigenic functions | eLife
TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions | eLife

p53 Is the Most Frequently Mutated Gene in Cancer, but Can We Target It?
p53 Is the Most Frequently Mutated Gene in Cancer, but Can We Target It?

High prevalence of TP53 loss and whole-genome doubling in early-onset  colorectal cancer | Experimental & Molecular Medicine
High prevalence of TP53 loss and whole-genome doubling in early-onset colorectal cancer | Experimental & Molecular Medicine